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| Achilles' Shield | 25 | Deal 10% more Spell and Weapon Damage while at 50% Health or higher. |
| Aite's Sword | 35 | You deal 125% more damage, but this Relic is fragile. |
| Amaterasu's Sun | 55 | Your Weapon applies (or extends) Burn for 2 seconds. |
| Ambrosia | 25 | After taking damage you are Invincible for an additional 1.25 seconds. |
| Ancestral Soul | 0 | Revive from mortal blows with 50% of your HP. Can occur 1 time. |
| Antikythera | 35 | Gain 10% Magic Damage per enemy defeated. Bonus lost when hit. (Max 50%). |
| Arcane Necklace | 25 | Cast 3 Spell(s) to charge the necklace, and make the next cast free. |
| Atrophos' Scissors | 25 | Critical damage from Spells and Weapons increased by 20%. |
| Blessing of Life | 0 | Take 30% Max HP damage. Increase Max HP by 15%. |
| Blessing of Strength | 0 | Deal 6% more Weapon Damage. |
| Blessing of Talent | 0 | Gain 20 Resolve. |
| Blessing of Wisdom | 0 | Deal 6% more Magic Damage. |
| Body Buffet | 35 | Defeated enemies have an 8% chance of dropping a Health Drop. |
| Boxing Bell | 45 | Your weapon applies Combo. |
| Catalyst | 25 | Deal 20% bonus damage to enemies with a Status Effect. |
| Charon's Trial | 0 | Cursed Relic. Until purified, any hit taken is Fatal. Defeat 15 enemies to purify it and gain a 20% Gold, Ore, and Aether bonus. |
| Clotho's Spindle | 25 | Critical chance for Spells and Weapons increased by 10%. |
| Coeus' Shell | 45 | Defeat 6 enemies to prevent the next source of damage. |
| Consume Nectar | 0 | Heals for 500% of Intelligence and restores 100% Mana. |
| Cornucopia | 25 | Health Drops restore an additional 8% of your Max Health. |
| Corrupting Reagent | 35 | After 3 Dashes, your next Dash will leave a poisonous cloud behind for 2 seconds. |
| Cosmic Insight | 25 | Gain 100 Mana when hurt. Mana gained can Overcharge. |
| Demeter's Trial | 0 | Until purified, any hit taken is Fatal. Collect 2 food/potions to purify this relic and gain 30% Max HP and 50 Mana. |
| Diogenes' Bargain | 15 | Oath Relic. No more gold. All Gold Bonuses are converted into an XP bonus instead (100% + your Gold Bonus). |
| Dreamcatcher | 35 | Defeat enemies while at Max HP to gain 5 Max Mana. (Max 200). |
| Empty Vessel | 25 | Gain 10% bonus Health, Weapon and Magic Damage. |
| Fate's Die | 25 | After defeating 6 enemies, the next non-special enemy hit dies instantly. |
| Freon's Reward | 25 | Opening Chests restores Health equal to 100% of Intelligence. |
| Glowing Ember | 25 | Deal 75% more damage on every 6th hit. Counter resets if you take damage. |
| Gnawed Bone | 25 | Eating Health Drops while at Full Health increases Max HP by 10% (Max 3 stacks). |
| Grave Bell | 35 | You have a 25% chance of avoiding a Fatal Blow. |
| Hector's Helm | 25 | While below 50% Health, deal 20% more Spell and Weapon damage. |
| Hermes' Boots | 35 | You are Immune to static spikes. |
| Heron's Ring | 35 | For every point of Resolve below 100%, deal an additional 1% bonus Magic damage. |
| Hyperion's Ring | 55 | Revive from mortal blows and regain 50% of your HP. Can occur 1 time(s). |
| Incandescent Telescope's Bargain | 15 | Oath Relic. Deal 25% more damage to enemies far away, but deal 25% less damage if they are nearby. |
| Ivy Roots | 25 | Deal 12.5% bonus damage while on the ground. |
| Ivy Seed | 25 | Create an Ivy Canopy every time you do an Aerial Recovery. |
| Lachesis' Measure | 55 | Enemies defeated with a critical hit restore 6% of your Max Health. |
| Lamech's Whetstone | 35 | Weapon Skill Crits now apply Magic Break for 2.5 seconds. |
| Lily of the Valley | 10 | Two are required to open the doors to Estuary Naamah. |
| Lotus Petal | 25 | Increase your total Mana Pool by 50. |
| Lotus Stem | 45 | Blocks up to 2 attacks. Consumes 150 Mana per block. Mana potions restore charges. |
| Marble Statue | 25 | Landing creates a small shockwave that destroys Mid-sized Projectiles and deals 50% Magic damage. |
| Obelisk | 25 | Your Skill Crits have an extra 20% chance of becoming Super Crits. |
| Onyx Key | 45 | A black key. (Used to open the Onyx Gate.) |
| Pandora's Trial | 0 | Cursed Relic. Until purified, any hit taken is Fatal. Defeat 10 enemies to purify this relic and gain 50 Resolve. |
| Pearl Key | 45 | A white key. (Used to open the Pearl Gate.) |
| Rage Tincture | 25 | After taking damage, deal 100% more damage during the Invincibility window. |
| Raven's Ring | 35 | For every point of Resolve below 100%, deal an additional 1% bonus Weapon damage. |
| Red Sand Hourglass | 25 | Every 5 seconds your next Weapon attack deals 75% bonus damage. Timer resets if you take damage. |
| Serquet's Stinger | 55 | Your Weapon applies 1 stack of Poison. |
| Skeleton Key | 35 | Open locked or melted Fairy Chests. Breaks after use. |
| Soul Tether | 45 | Every 5 seconds, your next attack deals 150% bonus Magic damage to all nearby enemies. |
| Steel-Toed Boots | 35 | Spin Kicks now apply Armor Break for 3.5 seconds. |
| The Future Successor's Bargain | 0 | Oath Relic. Depart this world. Increase your current Gold by 35%. (Instantly kills you.) |
| The Heavy Stone Bargain | 15 | Oath Relic. Your Weapon deals 100% more damage, but has a 2 second cooldown. |
| The Incarus' Wings Bargain | 15 | Your jump is replaced with Flight, but you take 100% extra damage. |
| The Serrated Handle's Bargain | 15 | Oath Relic. Deal and take 100% more damage. |
| Vanguard's Banner | 45 | Dashing creates a wave that destroys Mid-sized Projectiles. Waves travel 2 units. |
| Voltaic Circlet | 35 | Hitting an enemy with your Weapon will generate a damage aura around you for 1.5 seconds. |
| War Drum | 45 | Every unique relic increases your damage by 6%. |
| Weighted Anklet | 25 | Your Spin Kicks deal 25% more damage. |
| Weird Mushrooms | 35 | Defeated enemies have Spore Burst applied to them. |
| Zealot's Ring | 25 | Spells cast while at maximum Mana deal an additional 20% damage. |